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Vitamin D and Type I Diabetes
Research continues to pile up on the benefits of Vitamin D supplementation. Over 75 per cent of young type-1 diabetics may require vitamin D supplements, after a US study reported ‘surprisingly’ high levels of insufficiency. “We need to make sure all youths in general are getting enough vitamin D in their diets,” said Britta Svoren, MD, lead author of the study. “And, we need to pay particular attention to those with diabetes as they appear to be at an even higher risk of vitamin D deficiency.”

The researchers were interested in looking at vitamin D levels because of the vitamin’s presumed role in immune modulation and because it is thought to possibly play a role in the occurrence of type-1 diabetes. An earlier meta-analysis in the Archives of Disease in Childhood reported a potential protective role from vitamin D on the occurrence of type-1 diabetes.

Source: Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus.

Good news for those suffering with autism.
It appears that those with autism are characteristically depleted in glutathione and have difficulty with certain metabolic pathways including methylation. In a recent study, autistic children who were treated with a combination of methylcobalamin, the activated form of vitamin B12 and folinic acid, a form of folate, demonstrated a significant improvement in levels of plasma transmethylation metabolites and glutathione redox status.

Methylcobalamin and Folinic acid are both available in our supplement store. For more on specific supplementation for Autism, please consult with your doctor.

Source: Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.

Resveratrol and Breast Cancer Prevention

Scientists have identified some of the elusive downstream molecules that play a critical role in the development and progression of familial breast cancer and also identified a compound found in grapes and red wine as an excellent candidate for treatment of some forms of breast cancer.

About 8% of breast cancer cases are caused by mutations in tumor suppressor genes, such as breast cancer associated gene-1 (BRCA1). BRCA1 is the most frequently mutated tumor suppressor gene found in inherited breast cancers and BRCA1 mutation carriers have a 50-80% risk of developing breast cancer by age 70. Researchers were interested in investigating the relationship among BRCA1, SIRT1 and Survivin. SIRT1 is a protein and histone deacetylase involved in numerous critical cell processes including metabolism, DNA repair and programmed cell death. Survivin is an apoptosis inhibitor that is dramatically elevated in many types of tumors. Research has suggested that Survivin may serve to maintain the tumor and promote growth.

The researchers showed that the compound resveratrol strongly inhibited BRCA1-mutant tumor growth in cultured cells and animal models. The study demonstrated that resveratrol enhanced SIRT1 activity, which led to reduced Survivin expression and subsequent apoptosis of BRCA1 deficient cancer cells.

IPM carries a specialized form of reseveratrol, called Resveraguard that is highly absorbed. To order, please call reception at 949-600-5100.

Source: Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

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