Excelsa solution is a liquid blend of the sulfur containing compounds methyl-sulfonyl-methane (MSM) and dimethyl sulfoxide (DMSO). Studies have suggested both DMSO and MSM may have anti-inflammatory effects. MSM and DMSO have been used in patients with osteoarthritis and other inflammatory conditions including autoimmune diseases such as scleroderma and lupus. Many have reported success in the reduction of symptoms. In the body DMSO is converted to, and is the primary metabolite of DMSO in humans. Both substances are naturally occurring. Usual dose is 3 teaspoons a day orally, or as directed by your physician.