Hormone Pellets for Depression

Hormone pellets are tiny solid pieces of hormones, about the size of rice grains, comprised of either estrogen or testosterone. They are inserted under the skin on the side of the buttock, under local anesthesia. They reside in the layer of fat beneath the skin, from which they are slowly absorbed. They secrete constant amounts of hormones into the bloodstream, day and night, for 3-5 months, and sometimes longer.

Hormone PelletsI have been inserting hormone pellets into menopausal women, and into men with testosterone depletion, for a dozen years. Of all the methods of hormone restoration the pellets are the most potent, because blood levels do not fluctuate as they do with other formulations. Throughout their adult lives, women have experienced hormonal ups and downs related to ovulation and menstruation. Hormonal variations have incurred transient emotional changes in many women, manifested as anxiety, depression, insomnia and loss of libido. Often these emotional changes are aggravated with the onset of menopause, and relieved after bioidentical hormones are prescribed.Continue Reading

Testosterone Prevents Breast Cancer

A large study published in 2013 reveals a markedly reduced incidence of breast cancer in women treated with testosterone compared to women who received no hormone replacement therapy. (Glaser et al, Maturitas 2013)

Woman in Park1268 women were enrolled in the study, with average follow-up of five years. Treatment was provided with testosterone pellets implanted under the skin of the buttock or abdomen under local anesthesia, repeated every 3-4 months. About half of the implants contained testosterone alone, while the rest included anastrozole as well. Anastrozole blocks the conversion of testosterone into estrogen, offering added safety.

The incidence of breast cancer in the testosterone-treated group was only half that of women who did not receive hormones.

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Testosterone Replacement

There are so many diverse opinions about testosterone that it would be hard for anyone, physician or layman, to see a clear picture.

What is well established is that testosterone:

  1. Improves athletic performance
  2. Increases muscle mass
  3. Raises bone density
  4. Increases libido
  5. Often improves erectile function
  6. Reduces abdominal fat
  7. Increases red blood cell production

What has been argued is the effect of testosterone on heart disease, stroke, and mortality. A recent study reveals a powerful effect of testosterone in preventing heart attacks, stroke and death. (Normalization of Testosterone is Associated with Reduced Incidence of Myocardial Infarction and Mortality in Men, European Heart J. Aug 6, 2015)Continue Reading

Hormones and The Brain

BrainIn all the hullaballoo about hormone replacement therapy, not enough has been said about the profound effects of estrogen and testosterone on the brain. I think that if all the other benefits of hormone replacement were disregarded, the beneficial effects on brain function alone would justify prescribing them.

Women in menopause often develop depression, irritability, insomnia, memory loss, and a sort of cognitive disorientation. These symptoms can be severe, and psychiatric medications like sedatives and antidepressants are often inappropriately prescribed. Proper hormone therapy starts to improve these symptoms within two weeks.

Mental and emotional symptoms may persist long after other menopausal symptoms, like hot flashes and night sweats, have resolved. I recently saw a 65 year old woman who had been started on antidepressants years before to manage her depression. Her depression continued, and did not improve until she started hormone replacement therapy. A stronger hormone method completely resolved the depression and allowed her to discontinue antidepressant drugs. These were hormone pellets implanted under the skin of the buttocks. They maintain constant blood hormone levels for 3-4 months, without fluctuation, therefore provide stronger effects than creams, tablets, or patches.

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New Videos from Dr. Harden on Thyroid Treatment

Dr. Julie Harden recently spoke about different aspects of thyroid health, as well as The Institute for Progressive Medicine’s approach in treating and preventing hypothyroidism and hyperthyroidism. See the playlist of the 4 videos below:

Lose Weight With Testosterone

Healthy ManTestosterone deficiency is commonplace, and closely related to age. Levels decline 1% yearly after the age of 40. We also see declines in men under stress, either emotional or physical, and in men taking psychoactive agents such as antidepressants, sedatives, as well as alcohol and other drugs, particularly narcotics.

Testosterone is easily measured with a simple blood test. Deficiency is variously defined, but levels under 300 ng/dl are considered low. Treatment with testosterone by transdermal gel, injection or subcutaneous pellet will raise blood levels, and restore energy, libido, muscle mass, bone density, and sense of well-being.

A recent study reveals a further benefit with weight reduction and lower waist circumference. These improvements were progressive over 5 years, not limited to a few months after starting therapy.

The study, reported at the annual Endocrine Society meeting, involved 255 men averaging 61 years of age. All were obese or overweight. Testosterone levels normalized with long-acting intramuscular injections. Mean body weight dropped 16 kg (35 lbs) over 5 years. Waist circumference dropped an average of 8.8 cm (3 inches).

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Sermorelin – A Growth Hormone Stimulator

Government law restricts the use of human growth hormone (HGH) to three conditions: adult onset human growth hormone deficiency, inflammatory bowel disease, and adult immune deficiency syndrome (AIDS). The reason for this appears to be the unfair use of growth hormone by professional athletes to gain physical advantage over opponents. This situation is similar to the use of testosterone by athletes.

HGH, however, is beneficial in many ways. It increases bone density, heart muscle function, and connective tissue strength, reduces abdominal fat, and improves mental outlook and sense of well-being. Growth hormone levels decline with age, as does IgF1, a hormone made in the liver under the influence of growth hormone. Low IgF1 levels correlate with heart failure and general body decline.
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Testosterone Lengthens Life Span

Diabetic men with low testosterone levels had a death rate twice as high as diabetics with normal testosterone levels, followed over 6 years (20% versus 9%). When men with low testosterone were treated to restore normal levels, the risk of death was the same as men with normal testosterone levels. The study was published in Endocrine Abstracts (2011; 25:P163)

Most of the deaths were due to cardiovascular disease. Average age was 61 years. Testosterone therapy was regulated to restore the men to normal levels, and not higher.

Another study revealed transdermal testosterone replacement provided improvements in insulin resistance, total and LDL cholesterol, and sexual health.

Congestive heart failure is the major cause of hospitalization in people over the age of 65, causing one fifth of hospitalizations, or 875,000 admissions. Half of these patients die within five years.

Testing for testosterone deficiency should be performed in all men with heart failure. Low levels, below 320 ng/ml, should be treated with hormonal support, in the absence of active prostate cancer.

Allan Sosin MD

Thyroid Symptoms? Try Empirical Treatment

Many patients, most of them women, have symptoms suggestive of underactive thyroid glands, but thyroid blood tests are normal. They complain of constipation, hair loss, cold intolerance, low body temperature, weight gain, fatigue, depression, dry skin, and changes in menstruation. Unless blood tests are abnormal, many physicians decline to offer thyroid hormone therapy.

I have seen a number of patients whose symptoms markedly improved with thyroid hormone supplementation, even though thyroid blood tests were normal. The risk of providing low dose thyroid hormone, starting at 15 mg daily, is quite small, and we have seen no adverse effects at this dose. Symptoms, however, may improve remarkably.

The thyroid gland is sensitive to toxins, and in particular to gluten. Dietary restriction and detoxification have been shown to improve thyroid function. An initial trial of thyroid hormone may offer relief of symptoms while waiting for other changes to be made.

I also suggest a trial of detoxification for anyone with low thyroid. This involves taking nutrients to enhance hepatic detoxification and the release of toxins from fat cells where they are stored, combined with sauna therapy at 140-180 degrees. The program is followed daily for several weeks.

Studies were performed in firefighters and rescue workers engaged in the New York City 9/11 cleanup. Many of them had low thyroid function, which returned to normal after sauna and exercise detoxification.

Allan Sosin MD

Hormone Pellets and Osteoporosis: A Case Report

A post-menopausal woman had been diagnosed with osteoporosis, and was taking both Fosamax and transdermal hormone replacement therapy, without improvement. She did not want to continue taking Fosamax out of concern it would damage her jaw or cause swallowing problems, which bisphosphonates are reported to induce.

We stopped the Fosamax and began treatment with subcutaneous hormone pellets, both estrogen and testosterone. She also took calcium and magnesium, strontium and vitamin D. She continued to exercise actively on a daily basis.

Over the next four years, repeated bone density studies revealed a remarkable 20% increase in spine bone density. Osteoporosis had not only disappeared, but her bone density was now above average for her age.

This is the most dramatic example of hormone pellet effects on bone density, but we have seen positive effects in every individual tested. The pellets are highly effective, and should be considered for every appropriate individual, man or woman, who is at risk for fracture due to low bone density.

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Allan Sosin MD